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00335
	


    Mammalian Genome

Editors: J.H. Nadeau; S.D.M. Brown
ISSN: 0938-8990 (print version)
ISSN: 1432-1777 (electronic version)
Journal no. 335
Springer New York
Online version available <http://www.springerlink.com/content/0938-8990>
Online First articles available
<http://www.springerlink.com/openurl.asp?genre=issue&issn=0938-8990&volume=preprint&issue=preprint>


Description
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|
Editorial Board
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Instructions for Authors
Electronic Submission <#anchor1>
Manuscript Preparation <#anchor2>
Manuscript Style and Format <#anchor3>
Abbreviations and Nomenclature <#anchor4>
Guidelines for Electronically Produced Illustrations for Print <#anchor5>
Guidelines for Electronically Produced Illustrations for ONLINE <#anchor6>
Appendices and Supplementary Material <#anchor7>


Electronic Submission
Direct your manuscript to either of the two editors:

Joseph H. Nadeau
Genetics Department
Case Western Reserve University
10900 Euclid Avenue
Cleveland, OH 44106-4955
United States

Email: jhn4@po.cwru.edu

Steve D.M. Brown
Medical Research Council
Mammalian Genetics Unit
Harwell, Didcot
Oxfordshire 0X11 0RD
United Kingdom

Email: s.brown@har.mrc.ac.uk

EDITORIAL POLICY
Mammalian Genome publishes papers in all areas of genomic and genetic
research with mice, humans, and other mammalian species. Areas covered
include genetic and physical maps, genome organization and evolution,
comparative gene mapping, complex trait analysis, new techniques,
informatics as related to genome analysis, and human genetic disorders
and their analysis within model organisms

Mammalian Genome electronically processes all submitted manuscripts
through the online center, Manuscript Central
(http://mc.manuscriptcentral.com/mg). After your manuscript is
submitted, the Editors will inspect the submission online and assign
reviewers.


PLEASE NOTE: For review purposes, please save and upload your TEXT
(Title Page, Text, Acknowledgements, References, Tables, Legends) as one
file. FIGURES may be uploaded as separate files.


SYSTEM REQUIREMENTS
Authors will need the following in order to use Manuscript Central:




	
Netscape 4.x or MS Internet Explorer 4.x/5.x


	
Adobe Acrobat browser plug-in


	
Electronic file(s) of their article text.


	
Electronic files of their article graphics (scanned or exported)





AUTHOR ACCOUNTS
Authors entering the journal's Manuscript Central site can either create
a new account or use an existing one. When you have an existing account,
use it for all your submissions and you can track their status on the
same page. If you have submitted to Mammalian Genome before, please hit
the "check for existing account" button. You will then receive an
automatic e-mail with your user id and password. Otherwise please create
a new account and then follow the instructions given on the screen.


GETTING STARTED
Once you have logged into your account, Manuscript Central will lead you
through the submission process in a step-by-step orderly process. If you
cannot finish your submission in one visit, you can save a draft and
re-enter the process at the same point for that manuscript. While
submitting your electronic manuscript, you will be required to enter
data about your manuscript in the system. These include title, subtitle,
author names and affiliations, and so forth. Support for special
characters is available. At any point during this process, there are
Help buttons available to see common questions and a support link to ask
a specific question via email.


UPLOADING FILES
For review purposes, please save and upload your TEXT (Title Page, Text,
Acknowledgements, References, Tables, Legends) as one file. FIGURES may
be uploaded as separate files.


Electronic files can be uploaded as PDF, PostScript, or RTF. PDF and
PostScript files should already contain the graphics within the file.
(PostScript files are converted by the system into PDF so that Editors
and reviewers may share them. RTF (Rich Text Format) is a common export
property of most popular word processors. Check your word processor to
see if it can export or "SaveAs" your file in RTF format. MS Word and
WordPerfect both contain this function. After uploading the RTF for
text, you will be prompted for uploading graphics. Common graphics files
such as GIF, JPEG, EPS, TIFF and many others are supported.


After uploading the parts of the article in this manner, the system will
convert the files to PDF. You will see the result of the conversion with
the Acrobat plug-in in your browser. Keep copies of your word-processing
and graphics files. You may want to revise the manuscript during the
review process and you will need the original files if your manuscript
is accepted. At any point during this process, there are Help buttons
available to see common questions and a support link to ask a specific
question via email. You will also be notified by email that your
submission was successful.


GRAPHICS QUALITY
If you are submitting electronic graphics that you have scanned, be
prepared to send the hard copy originals upon request. While the
electronic files you have created are satisfactory for the review
process, they may not be of sufficient quality for printing. This also
holds true for files created in low-resolution graphics environments
such as MS Powerpoint, etc.


REQUIRED FORMS
Certain forms may be required upon submission, or acceptance, of your
manuscript. These forms can be found under the Icon, “Instructions and
Forms” in the upper right-hand corner of the Manuscript Central screen.
As soon as your manuscript has been submitted online, the “Copyright
Form” must be printed out, signed and sent without delay to the
Mammalian Genome Editorial Office at the following address:


Louise Tinsley, Managing Editor
Mammalian Genome
MRC Mammalian Genetics Unit
Harwell
Didcot
OX11 ORD
Tel: +44 (0) 1235 841275
Fax: +44 (0) 1235 841200
E-mail: l.tinsley@har.mrc.ac.uk


Other forms, such as the color reproduction form, may also be necessary
if the manuscript is accepted for publication. If your manuscript is
accepted, other hard copy items may also be requested later by the editors.


KEEPING TRACK
After submission, you may return periodically and monitor the progress
of your submission through the review process.


Manuscript Preparation
Two types of manuscripts will be considered for publication:



	
Articles should be a length appropriate to their findings, which, under
usual circumstances, is less than twenty (20) manuscript pages.
Information should be presented in the most efficient manner possible:
inclusion of material unrelated to the purpose or findings of the study
and the repetition of information in the Introduction, Results, and/or
Discussion sections should be avoided. Include only essential references
and avoid multiple citations from the same authors for any single piece
of information.


	
Reviews are normally commissioned by the editors. Authors should contact
them or send a short descriptive proposal before submitting a review.




Manuscripts are accepted for review with the understanding that they
have not appeared in print or been submitted for publication elsewhere
and that all authors have approved submission to Mammalian Genome.
Articles and other materials published in the journal represent the
opinions of the authors and do not necessarily reflect the views of the
editors or publisher. Authors submitting a manuscript do so with the
understanding that if accepted for publication, copyright (including the
right to reproduce the article in all forms and media) shall be assigned
exclusively to the publisher. The publishers will not refuse any
reasonable request by authors for permission to reproduce their
contribution.
During electronic submission you will have the option to direct your
manuscript for handling by either of the two editors:

5. Book, authored Blenkinsopp A, Paxton P. Symptoms in the pharmacy: a
guide to the management of common illness. 3rd ed. Oxford: Blackwell
Science; 1998.
Manuscript Style and Format
Manuscripts are submitted electronically through the journal web site
for manuscript submission and review, http://mc.manuscriptcentral.com/mg
and should be prepared using a word processing software package. The
preferred platform is Microsoft Word, for either Macintosh or Windows
operating systems. Manuscripts prepared with other word processors must
be converted to Word format for uploading to the journal site. The text
should be written using 2-line spacing, with about 1inch (2.5cm)
margins, on 8.5 x 11 inch (letter size) or A4 page formats. Lettering
should be 12 point (3 mm or 1/8 in). All pages should be numbered in
sequential order starting with the title page. Include first names for
all authors. Please follow the Guidelines for Electronically Produced
Illustrations for preparation of figures.


Manuscripts must be clearly and concisely written in English. They
should be carefully scrutinized for errors before they are submitted.
Correctness of spelling, grammar, and typing is the responsibility of
the author. Foreign contributors, whose language is not English, should
enlist the help of colleagues who are proficient in scientific English.
Laboratory slang, clinical jargon, and colloquialisms are not
acceptable. The Editors reserve the right to edit accepted manuscripts.


Full-length manuscripts should be organized as follows: Title page,
Abstract, Introduction, Materials and methods, Results, Discussion,
Acknowledgments (including sources of support), References, Tables, and
Figure legends. Please be sure to follow the journal style precisely in
the composition of the manuscript.


Manuscripts that do not conform to the conventions of the journal will
be returned to the author for revision.





Abbreviations and Nomenclature
Avoid using unnecessary abbreviations and do not abbreviate names of
organizations or institutions. The full term for which an abbreviation
stands should precede its first use in the text unless it is a standard
unit of measurement. Authors should use approved mouse nomenclature and
this should be obtained prior to submission from Lois Maltais, The
Jackson Laboratory, Bar Harbor, Maine 04609-0800, USA; tel: 207 288 6429;
fax: 207 288 6132; e-mail: nomen@informatics.jax.org;
http://www.informatics.jax.org/mgihome/nomen/index.shtml. Updated Mouse
Nomenclature Guidelines can be found online at
http://www.informatics.jax.org/mgihome/nomen/gene.shtml
Chemical abstracts should be used as a guide for other abbreviations and
symbols. Use S.I. units for linear dimensions, body mass, and clinical
chemistry. Use the degree Celsius for temperature.


Authors should use HUGO Gene Nomenclature Committee (HGNC) approved gene
symbols for human genes (http://www.gene.ucl.ac.uk/nomenclature/).
Symbols for human genes not found at the above website should be
obtained prior to submission from the HUGO Gene Nomenclature Committee
(HGNC), University College London, Wolfson House, 4 Stephenson Way,
London NW1 2HE, UK; tel: +44 207 679 7410; fax:+44 207 387 3496; e-mail:
nome@galton.ucl.ac.uk For guidelines see
http://www.gene.ucl.ac.uk/nomenclature/guidelines.html and Wain et al.:
Guidelines for human gene nomenclature. Genomics 2002; 79:464-470.



Standard Abbreviations currently being used are:


Chr Chromosome
Da dalton
kDa kilodalton
L liter
ml milliliter
PCR polymerase chain reaction
ORF open reading frame
cM centimorgan
bp base pair
SDS sodium dodecylsulfate
PAGE polyacrylamide gel electrophoresis
FISH fluorescence in situ hybridization
SSCP single strand conformational polymorphism
LINE long interspersed element
SINE short interspersed element
MHC major histocompatibility complex
HPLC high performance liquid chromatography
SSLP simple sequence length polymorphism
RFLP restriction fragment length polymorphism
PFGE pulsed field gel electrophoresis



Title page. The title page should be on a separate page and should
include the complete title, the first name, middle name initial, and
surname of all authors, as well as the institution of origin, including
city, state, zip code, and country. The title must be limited to 85
characters, including spaces. For multi-authored papers, correspondence
and page proofs will be sent to the first author, unless the editors are
instructed otherwise. The title page should also include a Fax number, a
voice phone number, and an E-mail address if one is available. A short
title for use as a running head (not to exceed 55 characters, including
spaces) should be provided.



Abstract. Abstract must not exceed 250 words and should state the
purpose of the study or investigation, basic procedures, main findings,
and principal conclusions. Emphasize new and important aspects of the
study or observations. It should be intelligible to scientists in other
specialties and generally understood without access to the entire
document. Avoid using references in the Abstract.



Introduction. State briefly the nature and purpose of the article and
refer to any relevant literature, concentrating on any recent important
work done by others. The repetition of information in the Introduction
and Discussion sections is undesirable.



Materials and methods. Include only those technical details that are
novel to the work presented in the manuscript. Provide citations only
for techniques and protocols essentially equivalent to those published
elsewhere.



Results and discussion. Explain your results, and define their
significance. Unsubstantiated speculation and plans for future study are
not appropriate.



References. Citations in the text should be by author and year. If there
are only two authors, both should be listed. If there are more than two
authors, only the first author's surname and "et al." are needed. Only
references cited in the text and accepted for publication should be
listed in alphabetical order by first author's surname in the reference
section. Please double-space the reference section. Journal
abbreviations listed in Index Medicus should be used. Unpublished data
should be referred to parenthetically in the text with the author's name
and "unpublished." Information provided by a colleague who is not an
author should be indicated with the colleague's name followed by
"personal communication." A letter from the colleague indicating
permission to use the information must be submitted with the manuscript.
Examples of reference format are the following:


Lyon MF (1984) Transmission ratio distortion in mouse t-haplotypes is
due to multiple distorter genes acting on a responder locus. Cell 37,
621-628


Sambrook J, Fritsch EF, Maniatis, T (1989) Molecular Cloning: A
Laboratory Manual, 2nd ed. (Cold Spring Harbor, NY: Cold Spring Harbor
Laboratory Press)


Arnheim N (1983) Concerted evolution of multigene families. In Evolution
of Genes and Proteins, M. Nei and R.K. Koehn, eds. (Sunderland, Mass.:
Sinauer Associates), pp 38-61



Tables. Tables should be numbered consecutively with arabic numerals in
order of appearance in the text and should be typed double-spaced on
separate pages. They should be collected together in numerical order
after the references. Table titles should be clear, concise, and
self-explanatory. A short descriptive caption should follow the title.
Footnotes, which should be indicated by superscript lowercase letters,
should be typed directly below the table. Complex tables may be
submitted as camera-ready copy. These tables should be single-spaced and
submitted as glossy prints, as well as conform to the journal's table
format.



Figures and illustrations. These should be numbered consecutively with
arabic numerals in order of appearance in the text. Figures with
biological information should be submitted as unmounted glossy prints.
Computer-generated line drawings can be submitted as laser printer
output on clean white paper. Each print should be identified on the
reverse with the first author's last name and figure number and with the
top of the figure or illustration marked. Figures should be designed to
fit into one column (3.25 in or 8.5 cm wide) or two (7 in or 8.5 cm)
with the final size of all lettering no larger than 12 point (3 mm or
1/8 in). Captions should be typed double-spaced on a separate page. The
total number of illustrations may not exceed one less than half of the
number of text pages. The additional cost of reproducing or printing
large quantities of figures may be charged to the author. Illustrations
that do not abide by these rules and those that do not make efficient
use of space will be returned to authors for re-drawing. This process
could hold up publication of accepted manuscripts. Color figures will be
printed at the author's expense: $1,150.00 per article.



Equations. Equations should be typewritten and the equation number, if
necessary, placed in square brackets at the right margin. Reference to a
specific equation should be written "Eq [1]."



Footnotes. Footnotes should be used sparingly, numbered consecutively,
and presented separately at the end of the manuscript.



Reviewing
All submitted manuscripts deemed appropriate for consideration by the
editors will be peer reviewed. Those not considered appropriate will be
returned to the authors immediately. Decisions on all papers
peer-reviewed are normally sent to authors by four (4) weeks after
submission.



Proofs
Page proofs will be sent to the corresponding author. Corrected proofs
must be returned within 48 hours. Authors will be charged for extensive
alterations.



Reprints
Reprints may be ordered at cost by using the form included with proofs.



Distribution of genetic materials Publication of an article in Mammalian
Genome is taken to indicate that the authors are prepared to freely
distribute to academic researchers for their own use any cell lines,
DNA, antibodies, mice, or other unique genetic materials used in the
experiments reported. Failure to comply with this policy may result in
exclusion from publication in Mammalian Genome.



Submission of information to genetic databases. Authors must provide
relevant information to the appropriate public databases before a
manuscript can be accepted for publication. Information and addresses
for the following databases are available from the Editorial Office:
Fundamental Genetic Databases for the Mouse (GBASE, HMDP, and MLDP),
GenBank and EMBL, Genome Database (GDB), and LODSOURCE (lod score for
pairs of genetic markers, including disease loci and DNA polymorphisms).
Accession numbers or copies of data-entry forms must be submitted to the
editors as proof of compliance.



New nucleotide date must be submitted and deposited in the
DDBJ/EMBL/GenBank databases and an accession number obtained before the
paper can be accepted for publication. Submission to any one of the
three collaborating databanks is sufficient to ensure data entry in all.
The accession number should be included in the manuscript as a footnote
on the title page: “Note: Nucleotide sequence data reported are
available in the DDBJ/EMBL/GenBank databases under the accession
number(s)………”. If requested the database will withhold release of data
until publication. The most convenient method for submitting sequence is
by World Wide Web:



EMBL via Webin: http://www.ebi.ac.uk/embl/Submission/webin.html
GenBank via Bankit: http://www.ncbi.nlm.nih.gov/BankIt/
DDBJ via Sakura: http://sakura.ddbj.nig.ac.jp/



Alternatively, the stand-alone submission tool ‘Sequin’ is available
from the EBI at http://www.ebi.ac.uk/Services/Sequin and from NCBI at
http://www.ncbi.nlm.nih.gov/Sequin/



For special types of submissions (e.g. genomes, bulk submissions etc)
additional submission systems are available from the above sites.



Contact Information: EMBL: EMBL Nucleotide Sequence Submissions,
European Bioninformatics Institute, Wellcome Trust Genome Campus,
Hinxton, Cambridge CB10 1SD UK; tel +44 1223 494400; fax: +44 1223
494472; e-mail: datasubs@ebi.ac.uk; http://www.ebi.ac.uk.



GenBank: National Center for Biotechnology Information, National Library
of Medicine, Bldg. 38A, Rm 8N-803, Bethesda, MD 20894, USA., tel: 301
496 2475; fax: 301 480 9241.



Protein sequences, which have been determined by direct sequencing of
the protein, must be submitted to SWISS-PROT at the EMBL Outstation—The
European Bioinformatics Institute. Please note that we do note provide
accession numbers, IN ADVANCE, for protein sequences that are the result
of translation of nucleic acid sequences. These translations will
automatically by forwarded to us from the EBML nucleotide database and
are assigned SWISS-PROT accession numbers on incorporation into TrEMBL.



Results from characterization experiments should also be submitted to
SWISS-PROT at the EBI. This can include such information as function,
subcellular location, subunit etc.



Contact Information: SWISS-PROT submissions, European Bioinformatics
Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD,
UK; tel +44 1223 494400; fax: +44 1223 494472; e-mail:
datasubs@ebi.ac.uk (for sequence submissions); update@ebi.ac.uk (for
characterization information); http//www.ebi.ac.uk


The HUGO Gene Nomenclature Committee (HGNC) is responsible for approving
and implementing unique human gene symbols and names, and works closely
with the Mouse Genome Database and other organism databases.
Considerable efforts are made to approve symbols acceptable to workers
in the field, but sometimes it is not possible to use exactly what has
previously appeared in the literature. In such cases the previously used
symbols are listed as aliases for the approved nomenclature in the HGNC
Database http://www.gene.ucl.ac.uk/cgi-bin/nomenclature/searchgenes.pl,
and other databases including Entrez Gene, to allow retrieval of all the
information available for each gene.


Copyright
Submission of a manuscript implies that the work has not been previously
published, nor is it under consideration for publication elsewhere.
Also, any coauthors must approve the article for publication; if the
manuscript is accepted for publication in Mammalian Genome, the
author(s) agree to automatic transfer of the copyright to the publisher.


Guidelines for Electronically Produced Illustrations for Print
GENERAL



	
Send illustrations separately from the text (i.e. files should not be
integrated with the text files).


	
You will be asked to send hardcopy originals of all figures upon
acceptance of your manuscript.





VECTOR (line) GRAPHICS



	
Vector graphics exported from a drawing program should be stored in EPS
format.


	
Suitable drawing program: Adobe Illustrator. For simple line art the
following drawing programs are also acceptable: Corel Draw, Freehand,
Canvas.


	
No rules narrower than .25 pt.


	
No gray screens paler than 15% or darker than 60%.


	
Screens meant to be differentiated from one another must differ by at
least 15%.





SPREADSHEET/PRESENTATION GRAPHICS



	
Most presentation programs (Excel, PowerPoint, Freelance) produce data
that cannot be stored in an EPS format. Therefore graphics produced by
these programs cannot be used for print.





HALFTONE ILLUSTRATIONS



	
Black & white and color illustrations should be saved in TIFF format.


	
Illustrations should be created using Adobe Photoshop whenever possible.





SCANS*



	
Scanned reproductions of black and white photographs should be provided
as 300 ppi TIFF files.


	
Scanned color illustrations should be provided as TIFF files scanned at
a minimum of 300 ppi with a 24-bit color depth.


	
Line art should be provided as TIFF files at 600 ppi.





* We do prefer having the original art as our printers have drum
scanners which allow for better reproduction of critical medical halftones.

GRAPHICS FROM VIDEOS



	
Separate files should be prepared for frames from a video that are to be
printed in the journal. When preparing these files you should follow the
same rules as listed under Halftone Illustrations.





Guidelines for Electronically Produced Illustrations for ONLINE
VIDEO



	
Quicktime (.mov) is the preferred format, but .rm, .avi, .mpg, etc. are
acceptable.


	
No video file should be larger than 2MB. To decrease the size of your
file, consider changing one or more of the following variables: frame
speed, number of colors/greys, viewing size (in pixels), or compression.
Video is subject to Editorial review and approval.





Appendices and Supplementary Material
Authors who wish to publish electronic supplementary material to their
article (Excel files, images, audio/video files) are requested to submit
their manuscript via our online submission system, with a note in the
author comments box that supplementary material will be submitted
separately by email. This email, containing the supplementary material,
should be sent to the Production Editor. In the email, the title of the
submitted manuscript as well as the name of the corresponding author
should be given.
		
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