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# Carcinogenesis

## Instructions to Authors

Carcinogenesis now welcomes submissions online. Once you have prepared your manuscript according to the Instructions below, please visit the online submission website

#### Scope and policy of Carcinogenesis

Carcinogenesis is a multi-disciplinary journal that brings together all the varied aspects of research that will ultimately lead to the prevention of cancer in man. The journal will publish papers that warrant prompt publication in the areas of Cancer Biology (including the processes of promotion, progression, signal transduction, apoptosis, genomic instability, growth factors, cell and molecular biology, mutation, DNA repair, genetics etc), Molecular Epidemiology and Cancer Prevention (including molecular dosimetry, epidemiology, genetic predisposition to cancer, chemoprevention, nutrition and cancer etc.) and Carcinogenesis (including viral, chemical and physical carcinogenesis, metabolism of carcinogens, and the formation, detection, identification and quantification of environmental carcinogens).

Papers considered by the Editors to be particularly timely and important will be given the status of Accelerated Papers that includes fast review and publication (-6 weeks). The Editors may, from time to time, invite short reviews. Authors wishing to submit a review should contact one of the Editors before submission.

#### Submission of manuscripts

Carcinogenesis now encourages online submission. Please visit http://carcin.manuscriptcentral.com

Alternatively, the manuscript (the original and two copies), along with a cover letter addressed to the Editor the authors would prefer to handle their manuscript (i.e. Drs Harris or Brown) should be submitted to one of the editorial offices.

For The Americas:

Dr C.C.Harris
Carcinogenesis Editorial Office
Oxford University Press
5235 Westview Drive
Suite 100
Frederick, MD 21703
USA

Tel: +1 (301) 846 0511
Fax: +1 (301) 846 0799
Email: curtis_harris@nih.gov

For Europe, Japan and the Rest of the World

Professor R Brown
CRC Department of Medical Oncology
Beatson Laboratories
University of Glasgow
Switchback Road
Glasgow G61 1BD
UK

Tel: +44 (0)141 330 4924
Fax: +44 (0)141 330 5654
Email: carcinogenesis@beatson.gla.ac.uk

Submission of a paper implies that it reports unpublished work and that it is not under consideration for publication elsewhere. If previously published tables, illustrations or more than 200 words of text are to be included, then the copyright holder's written permission must be obtained. Enclose copies of any such permission letters with your paper.

To decrease the time required for evaluation, the facsimile machine is now frequently used. The copies of manuscripts used for review will not ordinarily be returned to the authors unless specifically requested. Such a request will prevent the use of expedited fax responses during the review process. If a manuscript is accepted for publication, submission of the final version of the manuscript on a disc, along with a disc submittal form from a recent issue of Carcinogenesis, is encouraged. Authors should identify the section in which they wish their paper to appear i.e. Cancer Biology, Molecular Epidemiology and Cancer Prevention or Carcinogenesis in their letter of submission. This should also include names and addresses of 3 or 4 potential referees and, a justification of Accelerated Paper status if this is required.

#### Proofs

Authors will be sent page proofs. To avoid delays in publication, proofs should be checked immediately for typographical errors and returned to the publishers by express (special delivery) post. Alternatively, corrections may be given by telephone (01865) 556767 or by fax (01865) 267773. Essential changes of an extensive nature may be made only by insertion of a Note added in proof. A charge will be made to authors who insist on amendment within the text at the page-proof stage.

#### Preparation of manuscripts

Manuscripts should be in their final form when they are submitted so that proofs will require only correction of typographical errors.

Sections of the manuscript
Regular full-length papers should be subdivided into the following sequence of sections: Title page, Abstract, Introduction, Materials and methods, Results, Discussion, Acknowledgements, References, Tables, Legends to Figures. In the journal the Materials and methods, Acknowledgements and References will be printed in smaller type to accommodate more text.

#### General format

Manuscripts should be legibly typed on A4 or American quarto paper. All sections of the manuscript must be double-spaced (space between the lines of type not less than 6 mm). Margins of 25 mm (1 inch) should be left at the sides, top and bottom of each page. Number each page top right (Title Page is 1). Please avoid footnotes; use instead, and as sparingly as possible, parenthesis within brackets. Underline only words or letters to appear in italics. Clearly identify unusual or handwritten symbols and Greek letters. Differentiate between the letter O and zero, and the letters I and l and number 1. Mark the position of each figure and table in the margin.

#### Abstract

The second page of every manuscript must contain only the Abstract, which should be a single paragraph not exceeding 300 words. Please abide strictly by this limitation of length. Published papers will only have the first 300 words of their abstracts incorporated into Medline, text in excess of this limit will be lost. The Abstract should be comprehensible to readers before they have read the paper, and abbreviations and reference citations should be avoided.

#### Acknowledgements

These should be included at the end of the text and not in footnotes. Personal acknowledgements should precede those of institutions or agencies.

#### References

Authors are responsible for the accuracy of the References. Published articles and those in press (state the journal which has accepted them) may be included. Arrange references in numerical order with the numbers in the text in brackets and on the line (not as superscripts). Note that all authors' names should be mentioned and the initials follow the name; the date should precede the title; the title should be given in full; the name of the journal should be abbreviated according to the World List of Scientific Periodicals and underlined to indicate italics. References should therefore be listed as follows:

  1. Saffhill,R., Margison,G. and O'Connor,I. (1985) Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta, 823, 111-145.

  2. Hatch,F.T., Felton,J.S., Stuermer,D.H. and Bjeldanes,L.F. (1984) Identification of mutagens from the cooking of food. In de Serres,F.J. (ed.) Chemical Mutagens: Principles and Methods for their Detection. Plenum Press, New York, vol. 9, pp. 111-64.

  3. Bennett,M.V.L. and Spray,D.C. (1985) Gap Junctions. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

Personal communications (J.Smith, personal communication) should be authorized by those involved, in writing, and unpublished data should be cited as (unpublished data). Both should be used as sparingly as possible and only when the unpublished data referred to is peripheral rather than central to the discussion. References to manuscripts in preparation, or submitted but not yet accepted, should be cited in the text as (B.Smith and N.Jones, in preparation) and should NOT be included in the list of references.

#### Tables

Tables should be typed on separate sheets, and numbered consecutively with Roman numerals. Tables should be self-explanatory and include a brief descriptive title. Footnotes to tables indicated by lower case letters are acceptable, but they should not include extensive experimental detail. An arrow in the text margin should be used to indicate where a table should be inserted in the text.

#### Illustrations

All illustrations (line drawings and photographs) should be referred to in the text as Figure 1 etc., abbreviated to 'Fig. 1.' only in the figure legend. Write the title of your paper, the name of the first author and the figure number lightly in blue pencil on the back of each figure indicating clearly the top margin of each figure. Wherever possible figures will be sized to fit the width of a single column of text, i.e. 88mm wide. The maximum width of a double column figure is 183mm, and the maximum depth is 240mm. Where figures are composed of several parts, they should be squared accurately and separated by ~5mm. Please consider the overall page dimensions and layout, and the final reduction necessary for printing. Any lettering should be ~2mm in height in the printed figure (after reduction) and should be in proportion to the overall dimensions of the drawing. Labels should not be disproportionally large, and should show up clearly against the background.

#### Photographs

Wherever possible, these must be submitted in the desired final size so that reduction can be avoided. Ideally, photographs should fit either a single column (88mm) or a double column (183mm). Photographs should be of sufficiently high quality with respect to detail, contrast and fineness of grain to withstand the inevitable loss of contrast and detail inherent in the printing process. Please indicate the magnification by a rule on the photographs.

#### Colour figures

Inclusion of colour figures will be subject to a special charge. Details of charges are available on request from:

Production Editor (Carcinogenesis Journal)
Oxford University Press
Great Clarendon Street
Oxford, OX2 6DP
UK

If there is a choice of colours on a schematic, please choose clearly distinct colours (e.g. not two shades of blue) and avoid black backgrounds if possible.

#### Line drawings

Please provide clear, sharp prints, suitable for reproduction as submitted. No additional artwork, redrawing or typesetting will be done. Therefore, all labelling should preferably be made with a lettering set. Ensure that the size of lettering is in proportion with the overall dimensions of the drawing. Ideally, line drawings should be submitted in the desired final size to avoid reduction (maximum dimensions 248 x 185 mm including legends) and should fit either a single (88 mm) or a double column width (185 mm). If submitting line drawings which require reduction, please check that the lettering will be clearly legible after reduction to the size at which it will be printed. After reduction, letters should not be smaller than 1.5 mm in height.

#### Figure legends

These should be on a separate, numbered sheet. Define all symbols and abbreviations used in the figure. Common abbreviations and others in the preceding text should not be redefined in the legend.

#### Conventions

In general, the journal follows the conventions of the CBE Style Manual (Council of Biology Editors, Bethesda, MD, 1983, 5th edn).
Follow Chemical Abstracts and its indexes for chemical names. For guidance follow the recommendations issued by the IUPAC-IUB Commission on Bio-chemical Nomenclature, as given in Biochemical Nomenclature and Related Documents, published by the Biochemical Society, UK. For enzymes, use the recommended name assigned by the IUPAC-IUB Commission on Bio-chemical Nomenclature, 1978, as given in Enzyme Nomenclature, published by Academic Press, New York, 1980. Where possible, use recommended SI (Systeme International) units.
Genotypes should be italicized (underline in typed copy); phenotypes should not be italicized. For bacterial genetics nomenclature follow Demerec et al. (1966) Genetics, 54, 61-76.

#### Abbreviations

Restrict the use of abbreviations to SI symbols and those recommended by the IUPAC. Abbreviations should be defined in brackets after their first mention in the text. Standard units of measurements and chemical symbols of elements may be used without definition.

#### Policy concerning availability of materials

It is understood that by publishing a paper in Carcinogenesis the authors agree to make freely available to colleagues in academic research any of the cells, nucleic acids, antibodies, animals etc. that were used in the research reported and that are not available from commercial suppliers.

#### Copyright and Conflict of Interest

It is a condition of publication in the Journal that authors assign or licence copyright to Oxford University Press. This ensures that requests from third parties to reproduce articles are handled efficiently and consistently and will also allow the article to be as widely disseminated as possible. In assigning copyright, Authors may use their own material in other publications provided that the Journal is notified and acknowledged as the original place of publication, and that Oxford University Press is notified in writing and in advance.
  Carcinogenesis policy also requires that all authors sign a conflict of interest statement. If the manuscript is published such information may be communicated in a note following the text and reference.

  #### Offprints

  The publishers supply 30 reprints free of charge. Reprint order forms are sent out with the proofs, and must be returned with the proofs if extra reprints are required. Late orders submitted after the journal is printed are subject to increased prices.