Skip Navigation <#content>

*Oxford Journals </>*

    * Contact Us </contact_us.html>
    * My Basket <https://secure.oxfordjournals.org/basket.html>
    * My Account
      <http://services.oxfordjournals.org/cgi/tslogin?url=/service/Register>


  Toxicological Sciences </our_journals/toxsci/>

    * About This Journal </our_journals/toxsci/about.html>
    * Contact This Journal </our_journals/toxsci/cgi/feedback/>
    * Subscriptions </our_journals/toxsci/subscriptions/index.dtl>
    * Current Issue </our_journals/toxsci/current.dtl>
    * Archive </our_journals/toxsci/archive/>
    * Search </our_journals/toxsci/search.dtl>

    * Oxford Journals </>
    * Life Sciences </subject/life_sciences/>
    * Toxicological Sciences </our_journals/toxsci>
    * For Authors </our_journals/toxsci/for_authors>
    * Manuscript Preparation Guidelines


  Manuscript Preparation Guidelines

Manuscripts are to be submitted to /Toxicological Sciences/ through
/Toxicological Sciences/ Manuscript Central (/ToxSci/ MC) located at
http://mc.manuscriptcentral.com/toxsci. If you do not have access to the
Internet, please contact the editorial office at 302-326-9313.

Upon submission of a manuscript through /ToxSci/ MC, it is understood
that: (1) All authors have made a significant contribution to the paper
and share responsibility for it. (2) All authors have read and approved
the final version submitted, and the final version has been approved by
the institution where the work was carried out. (3) The manuscript has
not been previously published and is not under consideration elsewhere.
(4) Any potential conflict of interest has been disclosed to the Editor.

Please read the /Guidelines Governing Conflict of Interest/
<conflictofinterest.html>, which are posted on this Web site. The
Guidelines were also printed as part of the Editorial in the April 2003
(Vol. 72, No. 2) issue of /Toxicological Sciences/. You will be required
to disclose any potential conflicts within your manuscript submission.

_Cover letter_. A cover letter (if you choose to submit one), saved in
Microsoft Word format (.doc) or rich text format (.rtf), may be uploaded
in /ToxSci/ MC with other supporting documents.

_Preparation of manuscripts_. All manuscripts must be typed
double-spaced (including references) with 1-in. margins on all sides.
Prepare any text documents using a word-processing program, and save as
.doc or .rtf files. Make sure all tracked-changes comments are removed
from the final document. Tables should be saved at the end of the main
document. Do not embed figures in the text. *Please note: This journal
does not accept Microsoft Word 2007 documents at this time. Please use
Word's "Save As" option to save your document as an older (.doc) file
type.*

Page 1 should contain the /article title/, the /names/ and
/affiliations/ (include city, state, postal code and e-mail address) of
all authors, and the name and express delivery address (include street
or building name) of the corresponding author, along with e-mail address
and telephone and fax numbers. Affiliation callout symbols order is: *,
†, ‡, §, ¶, ||, lll, llll, #, **, ††. If there are anymore, then
lowercase superscript letters are used. It should also contain a short
title (not to exceed 40 characters). The article title should be
comprehensive and descriptive; proprietary names must not be used in
titles, but may be identified at first appearance in text. Authors
should suggest a section for their manuscript from the list located in
About the Journal
<http://www.oxfordjournals.org/our_journals/toxsci/about.html>.

Page 2 should contain an /abstract/, limited to 250 words, containing a
concise summary of what was done, the results obtained, and valid
conclusions drawn therefrom. It must mention the compounds or families
of compounds studied, their actions, and the species of animals used in
the research. It must not contain proprietary names or reference
citations. The abstract should be followed by a list of 3 to 6 key
words. Subsequent pages should contain the following sections:

_Introduction_. State why the investigation was carried out, note any
relevant published work, and delineate the objective of the
investigation. The significance of this work and its contribution to the
area of study should be stated. The Introduction should not exceed 750
words.

_Materials and Methods_. New methods or significant improvements of
methods or changes in old methods should be described. Methods for which
adequate reference can be cited are not to be described. In the
Materials and Methods section, authors should draw attention to any
particular chemical or biological hazards that may be involved in
carrying out the experiments described. Any relevant safety precautions
should be described; if an accepted code of practice has been followed,
a reference to the relevant standards should be given.

_Results_. Duplication between the text of this section and material
presented in tables and figures should be avoided. Tabular presentation
of masses of negative data must be avoided and replaced with a statement
in the text whenever possible. The statement must include (a) what was
done, (b) how it was done, (c) how the data were analyzed, (d) a measure
of variability, and (e) the significance of the result.

_Discussion_. This section must relate the significance of the work to
existing knowledge in the field and indicate the importance of the
contribution of this study. Needless detailed recapitulation of the
results should be avoided. Unsupported hypotheses and speculation should
be omitted. The Discussion should not exceed 1500 words.

_Supplementary Data (if applicable)_. This section should contain a
brief description of any supplementary data to be published online with
your article. The information you provide will be used to describe
supplementary data content and will appear in the print version after
the main body of the article.

Supplementary Data is supporting material that cannot be included in the
printed version for reasons of space, and that is not essential for
inclusion in the full text of the manuscript but would nevertheless
benefit the reader. It should not be essential to understanding the
conclusions of the paper but should contain data that is additional or
complementary and directly relevant to the article content.

Supplementary data will be made available by the publisher as
online-only content linked to the online manuscript. Such information
includes more detailed methods, extended data sets/data analysis,
tables, or additional figures (including color). In addition, other
material, including video clips and sound files, that enhance or extend
the context of the paper beyond that which can appear in print are welcome.

Supplementary data will be subject to the same editorial standards and
peer review process as the printed article and must be submitted along
with the main manuscript. The information should be submitted in
separate files and clearly designated as "Supplementary." Also ensure
that the supplementary data is referred to in the main manuscript at an
appropriate point in the text.

We also ask that you provide a brief description of the supplementary
data. The information you provide will be used to describe supplementary
data content and will appear in the print version after the main body of
the article.

When a revised manuscript (after peer review) is submitted, the
supplementary data should again be uploaded. It must be supplied to the
production department with the article for publication, not at a later
date. It cannot be altered or replaced after the paper has been accepted
for publication. Supplementary data will not be copyedited, so it is
important that the data are clearly and succinctly presented, and that
the style of terms conforms with the rest of the paper. The authors
should also ensure that the presentation will work on any Internet
browser. Please go to
http://www.oxfordjournals.org/our_journals/toxsci/for_authors/suppdata.html
for more information.

Acceptable formats for Supplementary Data
Files for supplementary data should be clearly marked as such and be
accompanied by a summary of the file names and types. A maximum of 5
files is acceptable to make up the supplementary data unit for an
article. The maximum size per file should not exceed 2 MB (although text
files should be a great deal smaller), and files should be as small as
possible, so that they can be downloaded quickly. An HTML index page is
created to link the supplementary data file(s) to the article. Please
provide short (2-4 word) titles for each individual file--these will be
used to create links to the files from the index page.

Recommendations for Supplementary Data

    * Use a common cross-platform (PC, Mac, Linux/UNIX, etc.) format for
      supplementary data to allow the greatest access for your readers.
    * Provide text files in Portable Document Format (.pdf), Microsoft
      Word (.doc), HTML (.html), or Rich Text Format (.rtf). Files
      supplied in Word or RTF may be used to create a PDF file.
    * Provide spreadsheet files in Microsoft Excel (.xls) or CSV (.csv)
      format.
    * Provide image files as Tagged Image Format (.tif), Graphic Image
      Format (.gif), or JPEG (.jpg). Images should be a maximum size of
      640 x 480 pixels (9 x 6.8 inches at 72 pixels per inch).
    * The preferred and most common format for movie clips is MPEG Movie
      (.mpg), although QuickTime Video (.mov) and Microsoft AVI Video
      (.avi) formats are also acceptable.

If you require further help or information regarding submission or
preparation of supplementary data, please contact the Managing Editor at
ToxSci@toxicology.org
<javascript:encrypt(%20'toxsci',%20'bms.com',%20''%20)> or the
Production Editor at toxsci@oxfordjournals.org
<javascript:encrypt(%20'toxsci',%20'oxfordjournals.org',%20''%20)>.

_Funding._ Details of all funding sources for the work in question
should be given in a separate section entitled 'Funding'. This should
appear before the 'Acknowledgements' section. The following rules should
be followed: the full official funding agency name should be given, i.e.
‘National Institutes of Health’, not ‘NIH’; grant numbers should be
given in parentheses; multiple grant numbers should be separated by a
comma; agencies should be separated by a semi-colon; no extra wording
like 'Funding for this work was provided by ...' should be used; where
individuals need to be specified for certain sources of funding the
following text should be added after the relevant agency or grant number
'to [author initials]'. An example is given here: ‘National Institutes
of Health (CB5453961 to C.S., DB645473 to M.H.); Funding Agency
(hfygr667789).’

_References_. Authors are responsible for the accuracy of their
references. The references should be cited in the text by author name
with the year of publication in parentheses using the following format:
(Able and Baker, 2000) or Able and Baker (2000). The order for multiple
citations within parentheses in the text should be alphabetical. When
there are more than two authors for a reference, use the first author's
name followed by /et al/. in the citation. References are limited to 40
references and should be listed alphabetically and typed double-spaced
on separate sheets at the end of the paper with all authors included.
All papers cited in the text must be listed in the reference list and
vice versa.

For works by the same author(s) in the same year, order the works
alphabetically in the reference list by title and append a lowercase a,
b, c, etc. to the year of publication. Journal titles should be
abbreviated according to the latest edition of /Chemical Abstracts
Service Source Index/ or /Index Medicus/; each abbreviated title should
be followed by volume number in boldface type. Note the following styles
for references:

/Research article/
Karanth, S., and Pope, C. (2000). Carboxylesterase and A-esterase
activities during maturation and aging: Relationship to the toxicity of
chlorpyrifos and parathion in rats. /Toxicol. Sci./ *58,* 282-289.

/Book chapter/
Frank, A. A., Blythe, L. L., and Spencer, P. S. (2000). Aspects of
veterinary toxicology. In Experimental and Clinical Neurotoxicology (P.
S. Spencer, H. S. Schaumberg, and A. C. Ludolph, Eds.), 2nd ed., pp.
83-105. Oxford University Press, New York.

/Abstract/
Yee, S. B., Ganey, P. E., and Roth, R. A. (1998). Temporal relationships
in the augmentation of monocrotoline hepatotoxicity by bacterial
endotoxin. Toxicol. Sci. 42(Suppl.), 366 (Abstract).

/Advance Access/
Gilad, Y. and Lancet, D. March 5, 2003. Population Differences in the
Human Functional Olfactory Repertoire. /Mol. Biol. Evol./
10.1093/molbev/msg013

The same paper in its final form would be cited:
Gilad, Y. and Lancet, D. 2003. Population Differences in the Human
Functional Olfactory Repertoire /Mol. Biol. Evol./ *20*, 307-314. First
published on March 5, 2003, 10.1093/molbev/msg013

Only published material or material accepted for publication should be
listed in the references; personal communications, unpublished data,
manuscripts in preparation, etc., should be incorporated into the text
in parentheses.

_Footnotes_ should be kept to a minimum and identified in the text by
superscript Arabic numerals and cited consecutively throughout the
paper. All footnotes should be listed in order and typed double-spaced
on a separate sheet. Proprietary names of substances and names and
locations of suppliers should not be identified in footnotes; rather,
put this information inside parentheses within the Materials and Methods
section. If the paper has been presented orally in whole or in part, the
date and occasion should be included in an unnumbered footnote.

_Tables_ should be prepared in a word-processing program and included in
the main manuscript .doc or .rtf file, double-spaced on a separate page
with the title directly above the table. Do not use abbreviations in the
title. The title and footnotes must contain all the information
necessary to understand and interpret the table without reference to the
text. Number tables consecutively with arabic numerals. Information
applicable to the title or to full columns or rows may be placed in a
general Note. Other footnotes should be identified by superscript
lowercase italic letters and placed below the table, after the general
Note (if any).

Letters should be assigned to table footnotes alphabetically in order of
appearance as the table is read horizontally. Tables should be placed
after the figure legends at the end of the manuscript. All tables must
be cited in the text.

_Figures._

Presentation. Figures should be numbered consecutively with arabic
numerals. All legends should be included in the main document and should
define all symbols and abbreviations used in each figure; each figure
should also be cited within the text itself. All figures should be
planned to fit within the proportions of the printed page (7 1/8 in.
wide x 9 in. deep); wherever possible, they should be submitted in their
desired final size, and need to be at least the width of a single column
of text (3.5 in). Lettering on the original figure should be
professional quality or generated by high-resolution computer graphics
and should be large enough (10-12 points) to be legible after reduction
of the figure to single-column width. Differences in type size within a
single figure should be no more than approximately 15%, and freehand,
penciled, or typewritten lettering is not acceptable.

Symbols used to identify points within a graph should be large enough to
be easily distinguishable after reduction. Please note that in line
drawings, faint shading and stippling will be lost upon reproduction and
should therefore be avoided. Multipart figures should have the parts
labeled with letters (A, B, C, etc.) and should be combined onto one
page. Include the figure number within the file but not as part of the
image. No artwork, redrawing, or typesetting changes can be made to
submitted figures, so it is extremely important that all elements of a
figure be correct at submission.

Creation and format. Figures should be created as Encapsulated
Postscript (.eps) or Tagged Image Format (.tif) files at resolutions of
300 dpi (dots per square inch) for photographic and color images or 600
dpi for black and white line drawings. Use CMYK colors only. PowerPoint
may also be used for graphs only. Electron micrographs should be no
larger than 6.5 x 4.5 in, and magnification should be indicated by a bar
on the micrograph. Please use high-resolution original sources, such as
scanned original artwork or original image files, to create your .tif or
.eps figures, with fonts embedded. For EPS submissions, please use the
following fonts only: Arial, Courier, Times New Roman, Helvetica, and
Symbol.

Even when saved as .tif or .eps files, graphics downloaded or saved from
Web pages (and other low-resolution materials) will not meet print
quality standards and are therefore unacceptable for figure creation.
Blurry, illegible, or other low-quality figures will be returned to you
for recreation and may delay publication of your paper.

We recommend that you produce your figures with high-quality graphics
software, such as Adobe Photoshop, to help ensure appropriate resolution
and workability. For instructions on how to use Photoshop and other
supported graphics software to prepare figures, please visit
http://cpc.cadmus.com/da/applications.asp. If the software available to
you cannot generate .tif or .eps files, you may wish to print a
high-quality copy of the figure, scan it, and then save it as a .tif.
For instructions on scanning, please visit
http://cpc.cadmus.com/da/scanning.asp.

For useful information on preparing figures visit http://dx.sheridan.com
<http://dx.sheridan.com > where you can also test whether your figures
are suitable for production by using the proflight tool at
http://dx.sheridan.com/onl/.

If your manuscript includes color figures or illustrations, please note
that there is a charge for publishing in color ($600 per color figure),
and you will be asked to defray the cost for publishing these figures.
If you are not able to cover the cost of color figures, please contact
the Editor.

Please submit figures containing color only if you want them to be
printed in color; color figures can be posted online as supplementary
data and published in the journal in black and white to control cost if
necessary. To ensure that your color resolutions and space requirements
meet the journal's standards, please visit
http://cpc.cadmus.com/da/guidelines.asp#rez.

Index terms suitable for use in the subject index may be submitted on a
separate page. The list should include chemical name, generic name, and
common name and may include the proprietary name of each important
substance used in experiments. It should also include biological
activity of each substance investigated. Terms should elucidate
important relationships.

_Microarrays._ Manuscripts summarizing the results of microarray
experiments must provide all microarray data at the time of submission.
Authors should provide a complete summary of the experimental results.
These data can be submitted to the journal as supplementary data or to a
reliable, unrestrictive archive for microarray results. If not submitted
to the journal, location information for the data must be provided.
Microarray experiments should also conform to standards outlined by the
Microarray Gene Expression (MGED) Society
www.mged.org/Workgroups/MIAME/miame_checklist.html. Authors may be
required to provide additional supporting evidence (such as real-time
PCR, in situ hybridization, Northern or Western blots or other methods)
to verify changes in genes deemed important to the interpretation of the
results.

_Nomenclature._ For styling of isotope, enzyme, and biomedical
nomenclature, consult the extended Instructions to Authors published in
each January issue of Archives of Biochemistry and Biophysics.

_Abbreviations._ Units will be in general accordance with the
International Systems (SI) as adopted by the 11th General Conference on
Weights and Measures. Periods are not used after abbreviations (note
exceptions, e.g., in. for inches). Common abbreviations to be used in
this journal are:

(Please note, some browsers are unable to render these characters. The
use of square brackets and the name of a symbol/Greek letter in this
HTML version signifies the use of that symbol/letter. If in doubt,
please refer to the printed copy of these instructions found in the
journal.)

    * *m* - meter
    * *cm* - centimeter
    * *mm* - millimeter
    * *[mu]m* - micrometer
    * *nm* - nanometer
    * *kg* - kilogram
    * *g* - gram
    * *mg* - milligram
    * *[mu]g* - microgram
    * *ng* - nanogram
    * *ml* - milliliter
    * *[mu]l* - microliter
    * *mol* - mole
    * *M* - molar
    * *mM* - millimolar
    * *[mu]M* - micromolar
    * *N* - normal
    * *Ci* - Curie
    * *[italic x with bar above it]* - mean
    * *ppm* - parts per million
    * *cpm* - counts per minute
    * *dpm* - disintegrations per minute
    * *sc* - subcutaneous
    * *ic* - intracutaneous
    * *im* - intramuscular
    * *ip* - intraperitoneal
    * *iv* - intravenous
    * *po* - oral
    * *LD[subscript 50]* - medial lethal dose
    * *LC[subscript 50]* - medial lethal concentration
    * *Hz* - hertz
    * *[degree]C* - centigrade
    * *s* - seconds
    * *min* - minutes
    * *h* - hours
    * *SD* - standard deviation
    * *SE* - standard error

_Submission for review._ Please create and save all of your documents as
previously described. Then combine all documents into one PDF file,
ensuring that all fonts are embedded and that no security settings are
selected. When submitting revisions, you will be required to upload a
revised PDF and individual word-processing and figure files as well as
all supporting documents (see Submission Checklist).


      Submission Checklist


      Initial submission

   1. Your initial submission for review should include:
          * __ One PDF file of all documents except supplementary data,
            for review. For instructions on creating this file, please
            visit http://mc.manuscriptcentral.com/toxsci. Be sure all
            fonts are embedded and no security settings are selected.
          * __ Clean copy (no highlighting) of above word-processing file.
          * __ Supplementary data, if applicable.
   2. __ Cover letter, if desired.


      Revision submission

   1. Your revised submission should contain the following:
          * __ Your revised word-processing file, including tables, in
            .doc or .rtf format, highlighted to show changes to the
            original submission.
          * __ A fair copy of the same file, excluding highlighting.
          * __ Each figure, saved in .tif or .eps format; .ppt may be
            used for graphs created in PowerPoint only.
          * __ Supplementary data as appropriate.
          * __ A revised PDF file containing all documents except
            supplementary data. If your manuscript is accepted, this
            file will be released publicly in Toxicological Sciences
            Advance Access. For instructions on creating this file,
            please visit http://mc.manuscriptcentral.com/toxsci. Be sure
            all fonts are embedded and no security settings are selected.
   2. The License to Publish form (available at
      http://www3.oup.co.uk/our_journals/toxsci/for_authors/
      </our_journals/toxsci/for_authors/>) should then be signed and
      faxed and mailed to the Production Department at Oxford University
      Press (fax number +44 (0)1865 355731).

_Granting of License._ Copyright of any article published in
Toxicological Sciences will belong to the author or his or her designee.
However, it is a condition of publication in the journal that authors
assign an exclusive license to the Society of Toxicology. Requests for
permission to repritn material found in the journal should be directed
to Oxford University Press. This ensures that requests from third
parties to reproduce articles are handled efficiently and consistently
and will also allow the article to be as widely disseminated as
possible. In assigning an exclusive license, authors may use their own
material in other publications written or edited by themselves provided
that the journal is acknowledged as the original place of publication
and Oxford University Press is notified in writing and in advance.

Upon submitting an article to the journal for review and possible
publication, authors are requested to add the following notice to the
first screen of any posted electronic preprint versions: "This work has
been submitted to /Toxicological Sciences/ for possible publication.
Exclusive license to publish may be granted without notice, after which
this version may no longer be accessible." Posting of the entire work is
regarded as prior publication.

When the editors of /Toxicological Sciences/ accept the work for
publication, it is posted in its accepted form as an Advance Access
article on the journal's Web site. New papers are put into Advance
Access at regular intervals and are then removed from the Advance Access
page once they have been copyedited, formatted, and paginated, at which
point the issue into which they are incorporated will be posted online.
Advance Access papers are fully integrated into the journal's online
system. Abstracts and titles are searchable and accessible within the
journal's Web pages, the entire HighWire archive, and PubMed.

_Content reproduction._ Permission to reproduce copyright material, for
print and online publication in perpetuity, must be cleared and if
necessary paid for by the author; this includes applications and
payments to DACS, ARS, and similar licensing agencies where appropriate.
Evidence in writing that such permissions have been secured from the
rights-holder must be made available to the editors. It is also the
author's responsibility to include acknowledgements as stipulated by the
particular institutions. Oxford Journals can offer information and
documentation to assist authors in securing print and online
permissions: please see the Guidelines for Authors
<http://www.oxfordjournals.org/access_purchase/rights_permissions.html>
section. Information on permissions contacts for a number of main
galleries and museums can also be provided. Should you require copies of
this, please contact the editorial office of the journal in question or
the Oxford Journals Rights <javascript:encrypt( 'journals.permissions',
'oxfordjournals.org', '' )> department.

_Proofs and offprints._ Authors are sent PDF page proofs. To avoid delay
in publication, proofs should be checked immediately for typographical
errors and returned to the publisher by fax (preferred) or express
delivery. A URL for unique access to the online version of each article
is supplied free of charge. An offprint order form will accompany the
proofs, and authors may purchase offprints and journal copies at a
discount (50%) using the form provided.


      Author Self-Archiving/Public Access policy from May 2005

For information about this journal's policy, please visit our Author
Self-Archiving policy
<http://www.toxicology.org/Information/news/TOXSCIOpenAccess.doc > page.


    The Journal

    * About this journal </toxsci/about.html>
    * Rights & Permissions </access_purchase/rights_permissions.html>
    * Dispatch date of the next issue
      <HTTP://www.oxfordjournals.org/access_purchase/dispatch_dates.html#TOXSCI>


      Published on behalf of

    * The Society of Toxicology <http://www.toxicology.org>


      Impact factor: 3.598


      Editor-in-Chief


        Lois D. Lehman-McKeeman

    * View full editorial board </toxsci/editorial_board.html>


    For Authors

    * Instructions to authors </toxsci/for_authors/index.html>
    * Online submission <http://mc.manuscriptcentral.com/toxsci >
    * Self-archiving policy
      <http://www.oxfordjournals.org/access_purchase/self-archiving_policya.html>

Open access options for authors

Open access options for authors - visit Oxford Open
<http://www.oxfordjournals.org/oxfordopen/>


    Alerting Services

    * Email table of contents </toxsci/cgi/alerts/etoc>
    * Email Advanced Access </cgi/alerts/etoc>
    * CiteTrack </toxsci/help/citetrack/index.dtl>
    * XML RSS feed </toxsci/rss>
    * PDA Access <http://highwire.stanford.edu/pda/?jcode=toxsci>


    Corporate Services

    * Advertising sales </corporate_services/advertising.html>
    * Reprints </corporate_services/reprints.html>
    * Supplements </corporate_services/supplements.html>

Online ISSN 1096-0929 - Print ISSN 1096-6080
Copyright © </toxsci/misc/terms.dtl> 2008 Society of Toxicology
<http://www.toxicology.org/>
*Oxford Journals* /Oxford University Press/

    * Site Map </site_map.html>
    * Privacy Policy <http://www.oup.co.uk/privacy/>
    * Frequently Asked Questions </faq/>

Other Oxford University Press sites:

