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Please read these instructions carefully and follow them strictly to
ensure that the review and publication of your paper is as efficient and
quick as possible. The Editors reserve the right to return manuscripts
that are not in accordance with these instructions. Please note that all
submissions must be accompanied by a manuscript submission form, a copy
of which can be found at the end of these instructions.


    SCOPE

/Human Molecular Genetics/ publishes papers of excellence, wide interest
and broad significance in all aspects of human molecular genetics. Areas
of interest include the molecular basis of human genetic disease,
developmental genetics, neurogenetics, chromosome structure and
function, molecular aspects of cancer genetics, gene therapy,
biochemical genetics and advances in gene mapping and understanding of
genome organization. Mutation reports are not normally considered unless
thay are of demonstrated functional significance or represent
documentation of mutations in newly isolated genes. In general, mapping
papers will be considered when they are of functional significance for
the field of molecular human genetics. The molecular analysis of other
organisms such as yeast, /Drosophila/, /C.elegans/ or mouse is also of
interest where such studies are relevant to the understanding of the
function of human genes. It is editorial policy not to publish Methods
papers unless they include information of biological significance.

There is considerable need to integrate the new disciplines of
comparative genomics and proteomics with modern genetics. In recognition
of this, /Human Molecular Genetics/ will now publish Articles in a
series entitled 'Genomes and Function'. This will contain contributions
describing computational studies that generate provocative hypotheses
for directing experimental research. By providing such hypotheses
through the pages of /Human Molecular Genetics/, computational biology
will improve its impact on genetics research.


    *REVIEW OF MANUSCRIPTS*

Papers will normally be reviewed within three to four weeks of
submission and will be published within six to ten weeks of acceptance.
Due to space restrictions and to the volume of high quality papers
submitted, the Editors reserve the right to return immediately those
papers which are unlikely to be competitive for space in the journal
and/or those which do not conform to the general editorial philosophy
and standards of/ Human Molecular Genetics./


      *Type of Manuscript*

The emphasis of the journal is on full research papers which may be of
any length required for concise presentation and discussion of the data.
Succinct and carefully prepared papers are favoured in terms of impact
as well as readability. Several different categories of paper are
published. While authors are invited to submit manuscripts in particular
categories, the Editors reserve the right to determine in which category
a paper is ultimately published, according to the criteria below.


        *Articles*

Articles are definitive and comprehensive descriptions of major research
findings of broad significance for readers of /Human Molecular
Genetics./ The results described should be both novel and of wide
interest. Articles may be of any length and may contain as many display
items as appropriate for the subject matter.


        Reports

Reports are descriptions of complete studies detailing results in areas
of interest to readers of /Human Molecular Genetics/. Reports are
typically less comprehensive than Articles and present data that are
generally of narrower interest within the field of human molecular
genetics. Reports may be of any length, although they are typically
shorter than Articles.


        Commentaries and Mini-Reviews

Commentaries and Mini-Reviews are published by invitation only. However,
proposals may be submitted in the form of a brief letter to the Editors
at any time. The letter should state the topic and authors of the
proposed review, and why the topic is of particular interest in the field.


    PREPARATION OF MANUSCRIPTS

Articles and Reports should be subdivided into the following sequence of
sections: Title page, Abstract, Introduction, Results, Discussion,
Materials and Methods, Acknowledgements, References, Legends to Figures,
Tables.


      General Format

The hard copies should be typed on A4 or American quarto (8.5 x 11
inches). Dot matrix print or any print that is difficult to read is
generally unacceptable. Please avoid the use of footnotes; use instead,
and as sparingly as possible, parentheses within brackets. Clearly
identify unusual or handwritten symbols. Do not use automatic page
numbering. It is recommended that authors spell-check their files before
submission.


      Title Page

The title should be short, specific and informative. The first name,
initial(s), and surname of each author should be followed by his or her
department, institution, city with postcode, and country. The fax and
telephone numbers and Email address of the corresponding author should
also be provided. It is editorial policy to list only one author for
correspondence. Any changes of address may be given in footnotes. A
footnote stating 'These authors contributed equally to this work' is
permitted. Any deletions from or additions to the author list after
acceptance of the paper must be submitted in writing, signed by all
authors, to the appropriate editorial office. New sequence accession
numbers (DDBJ/EMBL/GenBank) should be given.


      Abstract

The second page of the manuscript should contain the Abstract, which
must not exceed 250 words. The Abstract should be comprehensible to
readers before they have read the paper, and abbreviations and reference
citations should be avoided. It is essential that the Abstract clearly
states the biological importance of the work described in the paper.


      Materials and Methods

Names of suppliers should be given for materials used. Details of
centrifugation should be given in /g/ where possible; if centrifugation
is given in r.p.m., the rotor must be specified.


      Acknowledgements

These should be included at the end of the text and not in footnotes.
Personal acknowledgements should precede those of institutions and
agencies.


      References

These should be numbered in order of appearance in the text (in
parentheses) and must be listed numerically in the reference list. If an
automatic referencing system has been used in the preparation of the
paper, the references must not be left embedded in the final text file
submitted. The citation of journals, books and multi-author books should
conform to the following examples:

   1. Gorecki, D.C., Monaco, A.P., Derry, J.M.J., Walker, A.P., Barnard,
      E.A. and Barnard, P.J. (1992) Expression of four alternative
      dystrophin transcripts in brain regions regulated by different
      promoters. /Hum. Mol. Genet./, *1*, 505-510.
   2. Francis, V. and Bastin, M. (2000) Gene targeting in rat embryo
      fibroblasts promoted by the polyomavirus large T antigen. /Nucleic
      Acids Res./, in press.
   3. Maniatis, T., Fritsch, E.F. and Sambrook, J. (1982) / Molecular
      Cloning: A Laboratory Manual/. Cold Spring Harbor Laboratory
      Press, Cold Spring Harbor, NY.
   4. Huynh, T.V., Young, R.A. and Davis, R.W. (1988) DNA Cloning. In
      Glover, D.M. (ed.), /DNA Cloning - A Practical Approach./ IRL
      Press, Oxford, UK, Vol. 1, pp. 49 - 78. 

For references with >11 authors, the first 10 authors should be listed,
followed by /et al./.

References of the type Smith /et al./ (1989) should not be used in the text.
Personal communications (J. Jones, personal communication) must be
authorized in writing by those involved, and unpublished data should be
cited in the text as (unpublished data). References to manuscripts
submitted, but not yet accepted, should be cited in the text as (B.
Jones and L. Smith, in preparation) and should not be included in the
list of references. Citations of submitted manuscripts should include
all authors involved. Authors are encouraged to cite web URLs in
parentheses at the appropriate mention in the text. However, if the
details are lenghty and the website is cited several times, it may be
cited as a reference in the reference list.


      Illustrations

Wherever possible, figures should be submitted in their desired final
size, to fit the width of a single column of text (86 mm) or a double
column of text (180 mm).
Any lettering should be approximately 2 mm in height and should be in
proportion to the overall dimensions of the figure. On the back of each
figure, mark the number of the figure and the name of the first author,
and also indicate the top margin.

Photographs should be of sufficiently high quality with respect to
detail, contrast and fineness of grain to withstand the inevitable loss
of contrast and detail inherent in the printing process. When several
prints of the same figure are provided, please indicate which print
should be used for reproduction in the Journal.
There is a fee of £300 or $480 per figure for the inclusion of colour
figures. Written confirmation of intention to pay this fee for the
number of figures in the paper should be submitted with the manuscript.

Line drawings should have clear and sharp lines. Shading used on line
drawings should be clear and distinctive; shades of grey will not
reproduce well and small patches of white on an otherwise black
background are likely to be lost on reproduction.

Electronic images may be supplied in addition to, but not as substitutes
for, hard copies. Figures should be supplied in separate files, not
embedded in the text, and preferably on a separate disk to the text.
Minimum resolutions are 300 p.p.i. for colour or tone images, and 1200
p.p.i. for line drawings. The preferred format is TIFF. Colour figures
should be supplied in CMYK not RGB colours.

Changes to figures after acceptance and during proof stage will not be
allowed without permission from the Editors. Such changes may result in
additional charges and/or delays in publication of manuscripts.

Figure legends should be included on the disk where appropriate and also
on a separately numbered manuscript sheet. Symbols used in figures
should be limited to standard open and closed symbols (circles, squares,
triangles, diamonds). Symbols cannot be generated in the legend and
should be described rather than indicated by a symbol. Figures and
legends should be intelligible without reading the text of the manuscript.


      Abbreviations

Try to restrict the use of abbreviations to SI symbols and those
recommended by the IUPAC. Abbreviations should be defined and listed on
a separate page. Standard units of measurement and chemical symbols of
elements may be used without definition within the body of the paper.
Acronyms formed from phrases are unacceptable.


      Conventions and Nomenclature

In general, the Journal follows the conventions of the CBE Style Manual
(Council of Biology Editors, Bethesda, MD, 1983, 5th edn). Follow
Chemical Abstracts and its indexes for chemical names. For guidance in
the case of biochemical terminology follow the recommendations issued by
the IUPAC-IUB Commission on Biochemical Nomenclature, as given in
Biochemical Nomenclature, published by the Biochemical Society, UK.

For human genes, use genetic notation and symbols approved by the HUGO
Nomenclature Committee. Approved gene symbols should be obtained prior
to submission from the HUGO Nomenclature Committee,
nome@galton.ucl.ac.uk . For nomenclature guidelines, see White /et al./,
'Guidelines for Human Gene Nomenclature' [/Genomics/, *45*, 468-471
(1997)]. The Gene Name Proposal form may be completed on the
Nomenclature Web page: http://www.gene.ucl.ac.uk/nomenclature . Use ISCN
nomenclature for cytogenetics notation [Mitelman, F. (ed.) ISCN 1995: An
International System for Human Cytogenetic Nomenclature, S. Karger,
Basel]. Human gene names and loci should be written in uppercase italics
and Arabic numerals. Protein products are not italicized.

For mouse strain and genetic nomenclature, refer to the International
Committee on Standardized Genetic Nomenclature for Mice:
http://www.informatics.jax.org/nomen/table.html . New symbols and names
for genes should be obtained prior to submission through the online
symbol registry form at:
http://www.informatics.jax.org/nomen/nomen_submit.html .


    Accession numbers

Authors should be aware that all new sequence information, including
that which extends a previously determined sequence already present in
the database (and which already has an accession number), must be
submitted to any of the three major collaborative databases - DDBJ
(http://www.ddbj.nig.ac.jp), EMBL (http://www.ebi.ac.uk), GenBank
(http://www.ncbi.nlm.nih.gov) - for a new accession number. It is only
necessary to submit to one database, without regard to where the
sequence data will be published. Data are exchanged between DDBJ, EMBL
and GenBank on a daily basis. This number must be provided before
acceptance of the manuscript. Accession numbers from the major
collaborative databases should be cited in the text as (GenBank
accession no. AF149731). Other databases should be identified where used.


    Supplementary Material

Only directly relevant experimental data should be included in the full
text of manuscripts. Supporting data should be submitted for review as
supplementary material, alongside the original manuscript, for
publication online only. Material which has not been peer-reviewed will
be made available only through a link to the author's home page, at the
discretion of the Editor.


    SUBMISSION TO THE EDITORS

Three hard copies of the manuscript including all figures and tables,
clearly labelled, and a completed manuscript submission form should be
submitted as follows(a disk version should only be submitted with the
final revised manuscript and should be consistent with the hard copy).
Emailing the title page and abstract in advance to the editorial office
will expedite the review process. Please refer to the manuscript
submission form for the required formats.

*From the Americas, the Pacific and Australia to:*

The Editor
Human Molecular Genetics
Department of Genetics BRB 722
Case Western Reserve University
2109 Adelbert Road
Cleveland, OH 44106-4955
USA
Tel: +1 216 368 0199
Fax: +1 216 368 3030
Email: hmgjournal@po.cwru.edu

*From the Rest of the World to:*

The Editor
Human Molecular Genetics
Department of Human Anatomy and Genetics
University of Oxford
South Parks Road
Oxford OX1 3QX
UK
Tel: +44 1865 272416
Fax: +44 1865 272427
Email: helen.blaber@anat.ox.ac.uk

If a customs declaration is required, it is essential that the contents
be listed as OF NO COMMERCIAL VALUE. Bills for Customs or VAT will be
returned to the author. If the manuscript is rejected, normally only the
original figures are returned to the author. Submission of a paper
implies that it reports unpublished work and that it is not under
consideration for publication elsewhere. If previously published tables,
illustrations or more than 200 words of text are to be included, then
the copyright holder's permission must be obtained. Copies of any such
permission letters should be included with the paper.


      Disk submission

To assist rapid publication, all revised papers mustbe submitted on
disk. The computer format and word processor used must be clearly marked
on the disk and on the manuscript submission form. It is important to
note that material submitted to the Editors in disk form must also be
accompanied by three hard copies as above. See below for notes on disk
preparation.


    OFFPRINTS

The Journal will provide 30 free offprints of all articles to authors.
Offprint order forms are sent out with notification of acceptance and
must be returned to Oxford University Press, Great Clarendon Street,
Oxford, OX2 6DP, UK, if additional offprints are required. Late orders
submitted after the Journal has been printed are subject to increased
prices.


    POLICY

It is understood that by publishing a paper in /Human Molecular
Genetics/, the authors agree to make available to colleagues in academic
(non-profit) research any of the cells, nucleic acids, antibodies, etc.
that are not available from commercial suppliers and are required to
substantiate the scientific conclusions of the paper.


    COPYRIGHT

It is a condition of publication in the Journal that authors assign
copyright to Oxford University Press. This ensures that requests from
third parties to reproduce articles are handled efficiently and
consistently and will also allow the article to be as widely
disseminated as possible. In assigning the copyright, Authors may use
their own material in other publications provided that the Journal is
acknowledged as the original place of publication, and Oxford University
Press is notified in writing and in advance.

Authors are reminded that it is their responsibility to comply with
copyright laws. It is essential to ensure that no part of the text or
illustrations have appeared or are due to appear in other publications,
without prior permission from the copyright holder. Signed patient
consent forms must be obtained for recognizable photographs. Submission
of the manuscript will be taken to indicate the authors? compliance with
these conditions.

Manuscripts will not be published without submission of an original
signed copyright form, sent out with notification of acceptance (faxed
forms will not be accepted).


    REVISION OF MANUSCRIPTS

When a manuscript is returned to the authors for revision prior to final
acceptance, the revised version must be submitted within 1 month of the
author's receipt of the referees' reports. Revised manuscripts returned
after 1 month will be considered as new submissions subject to re-review.


    PUBLICATION

Manuscripts will usually be published within 2 months of acceptance.


    PAGE CHARGES

Page charges are NOT levied.


    PROOFS

If necessary to clarify queries, text proofs will be faxed to authors
before typesetting translation. In the interest of speed, corrections
must be returned within 24 hours. After page make-up, authors will
receive a pdf file of the complete paper by email. Again, corrections
must be returned within 24 hours. Hard copy proofs of colour figures
only (not black and white) will be mailed to authors for approval.


    GUIDE FOR AUTHORS PREPARING ELECTRONIC DOCUMENTS


      DO:

Enter text in the style and order of the journal.
Insert figure captions and tables at the end of the file.
Save any tables, diagrams, figures, graphs or illustrations generated
electronically as separate files and not embedded into the text file.
Type references in the correct order and style of the journal.
Type unjustified, without hyphenation, except for compound words.
Type headings in the style of the journal.
Use the TAB key once for paragraph indents.
Where possible use Times for the text font and Symbol for the Greek and
special characters.
Use the word processing formatting features to indicate Bold, Italic,
Greek, Maths, Superscript and Subscript characters.
Indicate clearly any special characters that you have drawn by hand on
the manuscript.
Check the final copy of your paper carefully, as any spelling mistakes
and errors will be faithfully translated into the typeset version.
Indicate on the form below the contents of each file.
Supply three hard copy printouts of the paper.


      DO NOT:

Enter carriage returns to obtain spacing between lines, paragraphs,
references, etc. The space required is generated automatically by the
typesetters.
Use double spaces after each sentence within a paragraph.
Use the automatic page numbering, running titles and footnote features
of your word processing programme: number the hard copy by hand at the
bottom of the page.
Include any copyright material (e.g. word processor software or
operating system files) on the disk.


      DISK SUBMISSION:

After the manuscript has gone through all the review and editing stages,
copy the data on to a 3.5 inch High Density disk. The data should be
saved in the word processing format and also as RTF (Rich Text Format).
To avoid confusion do not copy any irrelevant files and/or back-up files
on to the disk.
Apple Mac users should ensure the trash or wastebasket is empty before
submitting the disk.
Use the first-named author's name or manuscript number for the disk
label and file name.
To avoid loss or damage in transit ensure that the disk is adequately
protected and always keep a copy of the data on your computer and/or
back-up disk.
Please note that OUP does not intend to return the disk to the originator.


      FIGURE SUBMISSION:

Images on disk can be accepted in Adobe PhotoshopTM compatible formats.
Images should be saved in TIFF format.
Colour figures should be saved as CMYK colour rather than RGB.
Image resolution should be 300 p.p.i. for colour and half-tone figures
and 1200 p.p.i. for line figures.
Publication quality hard copies of all figures should be submitted and
will be used for reproduction if the electronic files cannot be used.

For further information contact

Academic Journals Production
Oxford University Press
Great Clarendon Street
Oxford OX2 6DP, UK
Tel: +44 1865 556767; Fax: +44 1865 267773


    OUP JOURNALS MANUSCRIPT/DISK SUBMISSION FORM

Completion of all the relevant sections of this form will assist in the
swift and efficient publication of your paper.

Manuscript Submittal Form
<http://services.oxfordjournals.org/cgi/tslogin?url=http%3A%2F%2Fwww.oxfordjournals.org%2Fhmg%2Finstauth%2Fhmg_disksub.pdf>
(10 KB PDF File).

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